Risk Assessment of Exposure to Vinyl Chloride
نویسنده
چکیده
Carcinogenic risk estimation of human exposure to vinyl chloride (VC) was determined by utilizing laboratory animal data on the chronic bioassay of VC, VC pharmacokinetics and VC macromolecular interaction. The impact of these data upon the type of risk VC may pose to humans and the selection of appropriate mathematical models to quantitatively estimate "risk" are discussed. The problem of estimating the carcinogenic risk of vinyl chloride (VC) exposure to humans is one that requires theintegration of information derived from several areas of toxicological research. The pharmacokinetics of VC in laboratory animals and the nature of the ultimate toxic species of VCmust be understood. The potential for VC to interact with critical macromolecules must be determined. Finally, the response of laboratory animals to the chronic exposure of VC as well as any human VC exposure data must be evaluated. Consideration of these three data bases on VC makes possible the application of appropriate mathematical models with which to more accurately assess the human carcinogenic risk of exposure to VC. The understanding of the kinetics of the metabolism of chemicals invivo is beneficial for the understanding of chronic bioassay results. As in the simplified example shown below, the parent compound (ç) may be excreted unchanged (Exc.) or be metabolized to a more reactive molecule (C ), which in turn may react with macromolecules (C-Macromol.), or be detoxified. C C C-Macromol. — Toxicity .— Detoxified Exc.
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